Multiple roles of glucose metabolism identified in platelet activation and survival

Platelet activation is reflected by multiple cellular changes and can be induced by diverse upstream inputs. Platelet activation requires glucose uptake that leads to the mobilization of intracellular calcium stores. Preventing platelet glucose uptake impairs platelet calcium metabolism that reduces platelet activation and increases platelet death and clearance from the circulation. Credit: Provided by University of Iowa Carver College of Medicine

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