Genes of a Human Origin play a Critical Role in Development of our Large Brains

Researchers studied the effects of NOTCH2NL genes in cortical organoids grown from human embryonic stem cells. Immunofluorescence staining shows markers for radial glia (green) and cortical neurons (red). Credit: Sofie Salama.

  • As shown in this diagram, the NOTCH2NL genes arose through a duplication event in a common ancestor of humans, chimpanzees, and gorillas, but only became functional genes in the human lineage. Credit: Sofie Salama