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RNA-Binding Proteins Could Be Promising Targets in Age-Related Dysfunctions

Jan 15, 2019 3:00 pm

As we age, our bodies undergo biological changes that cause a decline in the function of our cells and tissues. However, most studies attempting to identify molecules involved age-related dysfuncti...

Helping the Immune System Clear Away Old Cells in Aging Mice Helped Restore Youthful Characteristics

Jan 5, 2019 3:00 pm

If only we could keep our bodies young, healthy and energetic, even as we attain the wisdom of our years. New research at the Weizmann Institute of Science suggests this dream could be at least par...

Cell-free DNA (cfDNA) Has Something to Say about Our Biological Age

Dec 29, 2018 1:00 pm

Researchers have discovered age- and health-related differences in fragments of DNA found floating in the bloodstream (not inside cells) called cell-free DNA (cfDNA). These differences could someda...

Arthrology (6)

Neandertal Genes Shed Light on Endocranial Globularity of Modern Humans

Dec 17, 2018 6:00 pm

A characteristic feature of modern humans is the unusually round skull and brain, in contrast to the elongated shape seen in other human species. By studying Neandertal DNA fragments found in the g...

A Malfunctioning Gene May Associated with Ankylosing Spondylitis

Sep 4, 2018 11:00 am

A new Michigan State University study has found that a malfunctioning gene associated with a common arthritic disease that often starts in teenagers is now directly linked to the loss of vital immu...

a World With NO Arthritis

Feb 15, 2018 12:00 pm

There may come a time when people won’t require surgery to replace their joints. One researcher, Denis Evseenko, MD, Ph.D., a scientist at Keck School of Medicine at the University of Southern C...

Bacteriology (270)

How Can Bacteria Help Detect Cancer-Causing Proteins in Humans?

Jan 15, 2019 4:00 pm

A team led by researchers at Baylor College of Medicine and the University of Texas at Austin has applied an unconventional approach that used bacteria to discover human proteins that can lead to D...

Researchers Unlock Several Large Gene Clusters by Enticing Away the Repressors Dampening Silent Genes

Jan 6, 2019 4:00 pm

CHAMPAIGN, Ill. — By enticing away the repressors dampening unexpressed, silent genes in Streptomyces bacteria, researchers at the University of Illinois have unlocked several large gene clus...

Scientists Discover a Genetic Variant That Greatly Increases a Person's Likelihood of Developing Tuberculosis

Jan 6, 2019 12:00 pm

If you live in the United States, you are unlikely to come into contact with the microbe that causes tuberculosis. Your odds of encountering the microbe are so low, in fact, that risk factors for t...

Bioinformatics (219)

Are More Extensive Tests Causing Patients to Worry More About Their Cancer Risk?

Jan 9, 2019 3:00 pm

As genetic testing for breast cancer has become more complex, evaluating a panel of multiple genes, it introduces more uncertainty about the results. But a new study finds that newer, more extensiv...

Scientists Discover New Brain Changes in Early Alzheimer's Disease

Jan 2, 2019 12:00 pm

Researchers at the University of Eastern Finland have identified new early stages of Alzheimer's disease in the human brain by combining the findings of RNA and protein found in omika analyzes ...

How the Second X Chromosome in Women is Gradually Inactivated?

Jan 1, 2019 1:00 pm

In cell biology, men and women are unequal: men have an X chromosome, while women have two. How can we get around this difference? Geneticists from the University of Geneva (UNIGE), Switzerland, tu...

Biopharmaceuticals (99)

Researchers Unlock Several Large Gene Clusters by Enticing Away the Repressors Dampening Silent Genes

Jan 6, 2019 4:00 pm

CHAMPAIGN, Ill. — By enticing away the repressors dampening unexpressed, silent genes in Streptomyces bacteria, researchers at the University of Illinois have unlocked several large gene clus...

NSD2 Might Be a Therapeutic Target for Metastatic and Resistant Prostate Cancers

Dec 9, 2018 6:00 pm

A door opens to a new combined therapy to treat the most aggressive and resistant prostate cancers. This is one of the conclusions reached by researchers from the Institute of Biomedical Research o...

AstraZeneca provides Update on GALATHEA Phase III Trial for Fasenra in Chronic Obstructive Pulmonary Disease

Oct 10, 2018 9:00 am

AstraZeneca and MedImmune, its global biologics research and development arm, today announced top-line results from the GALATHEA Phase III trial for Fasenra (benralizumab) in patients with moderate...

Biotechnology (370)

How Can Bacteria Help Detect Cancer-Causing Proteins in Humans?

Jan 15, 2019 4:00 pm

A New Bioengineering Approach for Boosting Photosynthesis in Rice Plants

Jan 14, 2019 12:00 pm

A new bioengineering approach for boosting photosynthesis in rice plants could increase grain yield by up to 27%, according to a study publishing January 10 in the journal Molecular Plant. The appr...

How Genes and Neurons Work in Concert to Pick Out a Particular Scent?

Jan 12, 2019 2:00 pm

The human nose can distinguish one trillion different scents—an extraordinary feat that requires 10 million specialized nerve cells, or neurons, in the nose, and a family of more than 400 ded...

Cancer (1004)

Researchers Identify New Subtypes of B-ALL, With Distinct Genomic and Clinical Features

Jan 16, 2019 12:00 pm

Like cartographers completing a map, investigators have identified multiple new subtypes of the most common childhood cancer -- research that will likely improve the diagnosis and treatment of high...

How Can Bacteria Help Detect Cancer-Causing Proteins in Humans?

Jan 15, 2019 4:00 pm

Discovering a New Step in Assembly Line Which Controls the Expression of Some Genes with an Important Role in Cancer

Jan 15, 2019 1:00 pm

Genes contain all the information needed for the functioning of cells, tissues, and organs in our body. Gene expression, meaning when and how are the genes being read and executed, is thoroughly re...

Cancer Therapy (394)

The Role of Exosomes from Nischarin-Expressing Cells in Preventing Breast Cancer Growth and Spread

Jan 13, 2019 1:00 pm

Research led by Suresh Alahari, PhD, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has found a new role for a protein discovered by h...

Researchers Identify a Protein That Could Be a New Biomarker for Colorectal Cancers

Jan 12, 2019 12:00 pm

Johns Hopkins researchers have identified a protein involved in cell proliferation and the development of new blood vessels that could serve as a marker for the early detection of colorectal cancer...

Integrin CD11b Activation: A Novel Target for Cancer Immunotherapy

Jan 9, 2019 1:00 pm

Cancerous tumors trick myeloid cells, an important part of the immune system, into perceiving them as a damaged part of the body; the tumors actually put myeloid cells to work helping them grow and...

Cardiology (165)

Researchers Identify the Genetic Factor Associated with Atypical Heart Attack in Women

Jan 10, 2019 1:00 pm

New research published by teams from Leicester,UK and Paris, France in collaboration with international partners from the US and Australia, has found a common genetic factor that confers a signific...

New Stem-cell-based Test to Personalize Clinical Care for Family with Cardiomyopathy

Dec 27, 2018 4:00 pm

PHILDELPHIA – A little over a year ago, a 65-year-old woman with severe hypertrophic cardiomyopathy—a condition in which the heart’s muscle becomes abnormally thick, potentially c...

"SLCs" A Group of Genes Could Play Critical Roles in Atherosclerosis and Inflammatory Diseases

Dec 25, 2018 1:00 pm

A group of genes that has been largely ignored by scientists could play critical roles in atherosclerosis (hardening of the arteries), inflammation, and likely obesity and other metabolic diseases,...

Cell Biology (512)

RNA-Binding Proteins Could Be Promising Targets in Age-Related Dysfunctions

Jan 15, 2019 3:00 pm

A Third "Eye" in Algae Is Known: Researchers Discover a New Light Sensor with Unexpected Properties

Jan 13, 2019 2:00 pm

Scientists at the Universities of Würzburg and Bielefeld in Germany have discovered an unusual new light sensor in green algae. The sensor triggers a reaction that is similar to one in the hum...

New Insight into Early Development of Autism Spectrum Disorder

Jan 10, 2019 12:00 pm

Autism spectrum disorder (ASD) is a relatively common developmental disorder of communication and behavior that affects about 1 in 59 children in the US, according to the Centers for Disease Contro...

Cell Signaling (149)

Synapatic Protein That Regulates Anxiety Behaviors Offers a Therapeutic Target for Anxiety Disorders

Jan 7, 2019 1:00 pm

Anxiety disorders are severe mental disorders in which patients suffer from intense fears and anxiety or from sudden, inexplicable panic attacks. In extreme cases, the affected individuals rarely l...

How Hair Follicles Grow? New Findings Offer Answers to That Question

Jan 7, 2019 12:00 pm

An outstanding question in dermatology that researchers have studied for decades is: How do hair follicles emerge from a sea of seemingly uniform skin cells during embryonic development? New resear...

New Study Provides a Much-Awaited Explanation on the Role of Methionine in Sustaining Cell Growth

Jan 6, 2019 3:00 pm

For cells to grow and then divide, they must be in an anabolic state, where there is sufficient production of all necessary building blocks. It was earlier thought that as long as enough nutrients ...

Clinical Trials (145)

How Could Genetics Influence on Vitamin E Affect Cancer Risk?

Jan 12, 2019 1:00 pm

Almost half of all Americans take a vitamin supplement, and yet many large-scale, placebo-controlled clinical trials of various supplements have found little or no benefit. A new study led by inves...

A Large-Scale International Study Discover New Genetic Risk Loci for Alzheimer's Disease

Jan 9, 2019 4:00 pm

A large-scale international study has discovered new genetic risk loci for Alzheimer’s disease, and researchers published their work in Nature Genetics. Combining genetic data on a large...

A Live Genetically Engineered Vaccine Promises to Be Effective Against Chikungunya Virus

Dec 27, 2018 3:00 pm

(Vienna, 21 December 2018) A live vaccine genetically engineered from a common measles vaccine promises to be effective against the chikungunya virus. Such is the central finding of a recently comp...

Dentistry (13)

New Promising Period of Craniofacial Genetics

Jun 27, 2018 11:00 am

Our faces can reveal a lot about us, and now scientists are revealing a lot about faces. PLOS Genetics announces a special collection of papers to highlight recent advances in our understanding of ...

Instead of Filling Cavities, Dentists May Soon Regenerate Teeth

Mar 28, 2018 4:00 pm

For dentists, a cavity is a conundrum—in order to save the tooth they must further damage it. Currently, the primary way to treat a cavity is to excavate the decay and the surrounding area befor...

New Innovative Product To Preserve Oral Health

Dec 7, 2017 12:00 pm

Dentists rely on composite materials to perform restorative procedures, such as filling cavities. Yet these materials, like tooth enamel, can be vulnerable to the growth of plaque, the sticky biofilm ...

Dermatology (37)

How Hair Follicles Grow? New Findings Offer Answers to That Question

Jan 7, 2019 12:00 pm

New Insight into How the Immune System Can Be Hampered When it Comes to Fighting Cancer

Dec 4, 2018 2:00 pm

Over the course of evolution, the immune system has developed effective mechanisms to detect pathogens invading the body from outside and to eliminate them before they can cause major damage. Howev...

Asexual Reproduction Is the Rule for Trichophyton Rubrum

Jul 22, 2018 11:00 am

The sexual habits of Trichophyton rubrum, the fungus that causes athlete’s foot and other kinds of skin and nail infections, were the focus of a study published by Brazilian scientists and inter...

Developmental Biology (159)

How Hair Follicles Grow? New Findings Offer Answers to That Question

Jan 7, 2019 12:00 pm

New Evidence for Direct Genetic Effects in Sex-Based Differences in Neural Development

Jan 5, 2019 4:00 pm

Researchers have identified a group of genes that induces differences in the developing brains of male and female roundworms and triggers the initiation of puberty, a genetic pathway that may have ...

How Can Cannabis Affect the Genetic Profile of Users' Sperm?

Dec 29, 2018 3:00 pm

DURHAM, N.C. -- As legal access to marijuana continues expanding across the U.S., more scientists are studying the effects of its active ingredient, tetrahydrocannabinol (THC), in teens, adults and...

Diabetes (118)

What Could the Link between Type 2 Diabetes and Erectile Dysfunction Be?

Dec 23, 2018 12:00 pm

Evidence that type 2 diabetes is a cause of erectile dysfunction has been found in a largescale genomic analysis. The study, led by the University of Exeter and the University of Oxford, looke...

Scientists Try to Better Understand the Fundamentals of Blood Glucose Homeostasis and the Pathogenesis of Diabetes

Dec 17, 2018 3:00 pm

A recent study led by researchers in Texas A&M University's department of nutrition and food science shows how a novel regulatory mechanism serves as an important biomarker for the developm...

Cancer is Associated with an Increased Risk of Diabetes in Cancer Survivors

Sep 22, 2018 12:00 pm

A new retrospective Korean cohort study of more than half a million men and women followed for 10 years shows that a diagnosis of nine types of cancer was associated with a significantly increased ris...

Diseases (819)

An Immune Response Associated with the Development of Idiopathic Scoliosis (IS) Detected in Zebrafish

Dec 18, 2018 12:00 pm

Idiopathic scoliosis (IS) is a complex genetic disorder that affects approximately 4 per cent of children worldwide, yet its underlying biological cause remains unknown. Researchers at The Hos...

New Research Reveals the Three-Dimensional Structure of the DUX4 Protein Which Is Responsible for Muscular Dystrophy

Dec 15, 2018 4:00 pm

New research by University of Minnesota scientists has revealed the three dimensional structure of the DUX4 protein, which is responsible for the disease, facioscapulohumeral muscular dystrophy (FS...

Using in Vitro Cell Culture Could Contribute to a New Treatment for Schizophrenia

Dec 3, 2018 11:00 am

Belmont, MAA study recently published in Translational Psychiatry, a Nature journal, has shown how using cultured cells from patients with psychotic disorders, such as schizophrenia, to investigate...

Embryology (12)

New Research Identifies Two Proteins That Are the Keys to Decide Embryonic Cell Fate

Dec 15, 2018 1:00 pm

Mammalian embryos are unlike those of any other organism as they must grow within the mother’s body. While other animal embryos grow outside the mother, their embryonic cells can get right to...

The Secret behind Peace Agreement between Foetal Cells and Maternal Immune System

Dec 5, 2018 4:00 pm

The first Human Cell Atlas study of early pregnancy in humans has shown how the function of the maternal immune system is affected by cells from the developing placenta. Rese...

Scientists Produce Mouse Pups from Two Mothers by Using Stem Cells and Gene Editing

Dec 1, 2018 4:00 pm

Researchers at the Chinese Academy of Sciences were able to produce healthy mice with two mothers that went on to have normal offspring of their own. Mice from two dads were also born but only surv...

Endocrinology (36)

LncRNAs Appear to Be Responsible for Fine Regulation of Genes Involved in Prostate Cancer

Aug 9, 2018 10:00 am

In most cases of prostate cancer, tumor cell growth is stimulated by the action of male hormones, or androgens, such as testosterone and dihydrotestosterone (DHT). For this to happen, these ho...

The Latest Test for Thyroid Nodules

Aug 5, 2018 11:00 am

BOSTON — New data on the latest versions of two top genomic sequencing classifiers (GSC) demonstrate the increasing ability of molecular testing to assist in the management of patients with thyr...

Gestational Oral Low-Dose Estradiol-17β May Affect DNA Methylation in Embryos and Adult Offspring

Jul 5, 2018 11:00 am

The public debate on endocrine disrupting chemicals (EDCs) -- exogenous substances that have the same or similar effects as endogenous hormones -- has been going on for some time. Chemicals such as...

Epigenetics (108)

Discovering a New Step in Assembly Line Which Controls the Expression of Some Genes with an Important Role in Cancer

Jan 15, 2019 1:00 pm

How Genes and Neurons Work in Concert to Pick Out a Particular Scent?

Jan 12, 2019 2:00 pm

The human nose can distinguish one trillion different scents—an extraordinary feat that requires 10 million specialized nerve cells, or neurons, in the nose, and a family of more than 400 ded...

How Can Cannabis Affect the Genetic Profile of Users' Sperm?

Dec 29, 2018 3:00 pm

Evolution (126)

Neandertal Genes Shed Light on Endocranial Globularity of Modern Humans

Dec 17, 2018 6:00 pm

Researchers Find Revolutionary evidence That Epigenetics Works in Archaea

Dec 12, 2018 2:00 pm

University of Nebraska-Lincoln researchers have found revolutionary evidence that an evolutionary phenomenon at work in complex organisms is at play in their single-celled, extreme-loving counterpa...

New Insights into Longevity and Cognition Revealed by Parrot Genome Comparative Analysis

Dec 12, 2018 12:00 pm

Parrots are famously talkative, and a blue-fronted Amazon parrot named Moises—or at least its genome—is telling scientists volumes about the longevity and highly developed cognitive abi...

Featured (585)

Analyzing the Structure of RNAP in the Process of Melting DNA

Jan 15, 2019 2:00 pm

DNA is a molecular manual that contains instructions for building life. And, like any manual, DNA isn’t all that useful if it remains unopened and unread. In order to transcribe DNA, the enzy...

New Evidence for Direct Genetic Effects in Sex-Based Differences in Neural Development

Jan 5, 2019 4:00 pm

Researchers Unlock a Decades-Old Mystery about How & When DNA Replicates

Jan 3, 2019 2:00 pm

A team of Florida State University researchers has unlocked a decades-old mystery about how a critical cellular process is regulated and what that could mean for the future study of genetics. ...

Gastroenterology (66)

A Change in the Genome Might Offer Clues to Esophageal Cancer Disparity

Dec 22, 2018 4:00 pm

A change in the genome of Caucasians could explain much-higher rates of the most common type of esophageal cancer in this population, a new study finds. It suggests a possible target for prevention...

Optogenetics Provides a less Toxic Remedy to debilitating gastrointestinal conditions

Sep 10, 2018 11:00 am

A novel light therapy is being investigated as an alternative to prescription drugs to relieve chronic constipation and other intestinal disorders which affect millions of patients around the world. ...

A New Method to Identify Microbial Genes that Make Some Microbes Live in Your Gut

Aug 29, 2018 10:00 am

SAN FRANCISCO, CA—Trillions of tiny microbes and bacteria live in your gut, each with their own set of genes. These gut microbes can have both beneficial and harmful effects on your health, from...

Gene Therapy (98)

Using CRISPR to Modify Pig Genome Shows Promise Against Deadly Disease

Jan 3, 2019 1:00 pm

Chinese scientists recently reported that they have developed genetically modified pigs that are immune from the classical swine fever virus (CSFV). Classical swine fever, caused by CSFV, is h...

CRISPRa Fights Obesity Without Edits to Genome

Dec 29, 2018 2:00 pm

A weighty new study shows that CRISPR therapies can cut fat without cutting DNA. In a paper published Dec. 13, 2018, in the journal Science, UC San Francisco researchers describe how a modified ver...

"SLCs" A Group of Genes Could Play Critical Roles in Atherosclerosis and Inflammatory Diseases

Dec 25, 2018 1:00 pm

General (324)

A New Bioengineering Approach for Boosting Photosynthesis in Rice Plants

Jan 14, 2019 12:00 pm

A Third "Eye" in Algae Is Known: Researchers Discover a New Light Sensor with Unexpected Properties

Jan 13, 2019 2:00 pm

Scientists at the Universities of Würzburg and Bielefeld in Germany have discovered an unusual new light sensor in green algae. The sensor triggers a reaction that is similar to one in the hum...

A Potential Way to Fighting Human Disease through Mosquito Birth Control

Jan 10, 2019 2:00 pm

Depending on where you live, the buzz of a nearby mosquito can be a nuisance, or it can be deadly. Worldwide, more than 500 million people suffer from diseases transmitted by the blood-feeding inse...

Genetic Diseases (279)

A Genetic Test to Measure Sociability in Dogs

Dec 29, 2018 12:00 pm

Pet lovers seeking a better understanding of their four-footed friends might benefit from a new genetic test for sociability in dogs. While studying the genomes of canines, Bridgett vonHoldt, ...

Injection of Short RNA Molecule Improves Vision in Leber Congenital Amaurosis

Dec 27, 2018 2:00 pm

PHILADELPHIA -- A new treatment for patients with a form of congenital retinal blindness has shown success in improving vision, according to results published today in Nature Medicine led by resear...

Scientists Discover New Rare Mutation in MAPT Gene That Causes an Inherited Form of Frontotemporal Dementia

Dec 20, 2018 1:00 pm

Unlike the more common Alzheimer’s disease, frontotemporal dementia tends to afflict young people. It accounts for an estimated 20 percent of all cases of early-onset dementia. Patients with ...

Genetics (1369)

Researchers Identify New Subtypes of B-ALL, With Distinct Genomic and Clinical Features

Jan 16, 2019 12:00 pm

How Can Bacteria Help Detect Cancer-Causing Proteins in Humans?

Jan 15, 2019 4:00 pm

RNA-Binding Proteins Could Be Promising Targets in Age-Related Dysfunctions

Jan 15, 2019 3:00 pm

Genome & Genomics (359)

How Genes and Neurons Work in Concert to Pick Out a Particular Scent?

Jan 12, 2019 2:00 pm

The human nose can distinguish one trillion different scents—an extraordinary feat that requires 10 million specialized nerve cells, or neurons, in the nose, and a family of more than 400 ded...

A Large-Scale International Study Discover New Genetic Risk Loci for Alzheimer's Disease

Jan 9, 2019 4:00 pm

A large-scale international study has discovered new genetic risk loci for Alzheimer’s disease, and researchers published their work in Nature Genetics. Combining genetic data on a large...

BabySeq Project identifies Children Susceptible to Diseases That Regular Screening Doesn’t Look for

Jan 6, 2019 2:00 pm

The majority of babies born in the US undergo a hearing screening as well as a blood test to detect certain diseases that can be fatal if they go untreated, such as cystic fibrosis and phenylketonu...

Gynecology (45)

Only Sequencing Fetal DNA is Enough !!

Aug 11, 2018 12:00 pm

Sequencing the fetal DNA that circulates in a pregnant woman’s blood holds promise for modern genomic medicine, according to a review article by Diana W. Bianchi, M.D., a senior researcher and i...

A Genetic Variation in Progesterone Receptor Might Be Linked to Prematurity Risk

Jun 30, 2018 2:00 pm

Humans have unexpectedly high genetic variation in the receptor for a key pregnancy-maintaining hormone, according to research led by scientists at the Stanford University School of Medicine. The f...

Study Results Shows that a Blood Sample can Estimate Fetal Age and Follow up Growth

Jun 11, 2018 8:00 pm

Measuring RNA fragments in a pregnant woman’s blood gives a reliable estimate of the baby’s due date and can predict if the baby will arrive prematurely, a Stanford-led team has shown. ...

Hematology (103)

Uncovering the Unique Drug Susceptibility Patterns in Leukemia Cells Could Lead to Appropriate Treatment for AML

Dec 11, 2018 1:00 pm

Advances in rapid screening of leukemia cells for drug susceptibility and resistance are bringing scientists closer to patient-tailored treatment for acute myeloid leukemia (AML). Research on ...

Scientists Succeed in Turning Human Skin Cells into Blood Stem Cells for the First Time

Dec 8, 2018 12:00 pm

Transplantation of blood stem cells, isolated from mobilized peripheral blood or bone marrow, is a widely utilized therapy for a range of inherited and acquired blood disorders. Allogeneic transpla...

Healthy Blood Stem Cells Seem to Have as Many Mutations as Leukemic Cells!

Dec 2, 2018 11:00 am

Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ. Rather the location of th...

Histopathology (11)

A New Enzyme with an Abnormal Amino Acid in its Structure

Jul 14, 2018 12:00 pm

University of Groningen chemists have created a new enzyme with an unnatural amino acid as its active centre. They made the enzyme by modifying an antibiotic binding protein which normally acts as a b...

How Oncogenic Mutant Cells Lead The War Against Normal Ones To Expand Its Property in Tissue?

Jun 24, 2018 11:00 am

Cells in multicellular tissues adhere to each other. Epithelial tissues on the surface layer of the intestines and skin pack cells into a hexagonal (honeycomb) pattern, with cells adhering tightly ...

Surprising Discoveries Limit the Importance of Apoptosis in Embryonic Development

May 23, 2018 10:00 am

Australian researchers have made a surprise discovery that could rewrite our understanding of the role programmed cell death plays in embryonic development and congenital birth defects. The team sh...

Immunology (426)

The Possible Common Mechanism between Fungal Infections and the Development of Chronic Neurological Disorders

Jan 12, 2019 2:00 pm

Fungal infections are emerging as a major medical challenge, and a team led by researchers at Baylor College of Medicine has developed a mouse model to study the short-term consequences of fungal i...

New Evidence on the Importance of Gut-Brain Axis in Multiple Sclerosis

Jan 9, 2019 2:00 pm

Researchers at the University of Toronto and University of California, San Francisco have discovered that the intestine is the source of immune cells that reduce brain inflammation in people with m...

Integrin CD11b Activation: A Novel Target for Cancer Immunotherapy

Jan 9, 2019 1:00 pm

Infectious Diseases (141)

A Potential Way to Fighting Human Disease through Mosquito Birth Control

Jan 10, 2019 2:00 pm

Scientists Discover a Genetic Variant That Greatly Increases a Person's Likelihood of Developing Tuberculosis

Jan 6, 2019 12:00 pm

Researchers Discover New Connections between Ebola Virus and Human Proteins

Jan 5, 2019 12:00 pm

Several new connections have been discovered between the proteins of the Ebola virus and human host cells, a finding that provides insight on ways to prevent the deadly Ebola virus from reproducing...

Infertility (38)

How Can Cannabis Affect the Genetic Profile of Users' Sperm?

Dec 29, 2018 3:00 pm

Researchers Implement a Massive Sequencing Platform for (DF-PGT) for the First Time in History

Dec 16, 2018 3:00 pm

A research team from the Universitat Autònoma de Barcelona (UAB), in collaboration with the Blood and Tissue Bank of Catalonia, has managed to implement a massive sequencing platform for Pre...

New Discovery About The Role of Dark Matter in Human Sex Determination

Dec 16, 2018 11:00 am

Medical researchers at Melbourne's Murdoch Children's Research Institute have made a new discovery about how a baby's sex is determined—it's not just about the X-Y chromosomes...

Microbiology (203)

How Does Gut Microbiome Regulate the Host's Immune System?

Jan 2, 2019 2:00 pm

A new study in mice unveils the role of vitamin A in immune system regulation, a finding that could assist in developing treatments for autoimmune and inflammatory diseases as well as vitamin A def...

How the Distance of Microbial Competitions Shapes Their Community Structures?

Dec 8, 2018 10:00 am

Inside the microbial communities that populate our world, microbes are fighting for their lives. These tiny organisms are in the soil, in the oceans, and in the human body. Microbes play sever...

Creating Microbes with an Expanded Genetic Code Can Open Up New Avenues in Synthetic Biology and Protein Engineering

Dec 3, 2018 2:00 pm

Our genetic code is made up of four nucleotide bases, but in recent years, scientists have created microbes that incorporate totally new bases. That has opened up new avenues in synthetic biology a...

Molecular Biochemistry (514)

RNA-Binding Proteins Could Be Promising Targets in Age-Related Dysfunctions

Jan 15, 2019 3:00 pm

How Could Genetics Influence on Vitamin E Affect Cancer Risk?

Jan 12, 2019 1:00 pm

Researchers Identify a Protein That Could Be a New Biomarker for Colorectal Cancers

Jan 12, 2019 12:00 pm

Molecular Pharmacology (167)

New Compound Made of Cellular Prion Protein Shows Promise in Treatment of Alzheimer’s

Jan 10, 2019 4:00 pm

Yale researchers have identified a drinkable cocktail of designer molecules that interferes with a crucial first step of Alzheimer’s and even restores memories in mice, they report Jan. 2 in ...

Researchers Unlock Several Large Gene Clusters by Enticing Away the Repressors Dampening Silent Genes

Jan 6, 2019 4:00 pm

CHAMPAIGN, Ill. — By enticing away the repressors dampening unexpressed, silent genes in Streptomyces bacteria, researchers at the University of Illinois have unlocked several large gene clus...

Injection of Short RNA Molecule Improves Vision in Leber Congenital Amaurosis

Dec 27, 2018 2:00 pm

Mycology (9)

The Possible Common Mechanism between Fungal Infections and the Development of Chronic Neurological Disorders

Jan 12, 2019 2:00 pm

Asexual Reproduction Is the Rule for Trichophyton Rubrum

Jul 22, 2018 11:00 am

The sexual habits of Trichophyton rubrum, the fungus that causes athlete’s foot and other kinds of skin and nail infections, were the focus of a study published by Brazilian scientists and inter...

Identification of the Biosynthetic Gene Cluster for Highly Oxygenated Steroids Group Derived from Fungi

Jun 24, 2018 6:00 pm

A group of researchers from Graduate School of Pharmaceutical Sciences at The University of Tokyo and Institute of Traditional Chinese Medicine and Natural Products at Jinan University, identified ...

Nanotechnology (61)

Study Reveals a New Improvement on Single-Cell RNA Sequencing

Dec 24, 2018 1:00 pm

Droplet microfluidics has revolutionized single-cell RNA sequencing, offering a low-cost, high-throughput method for single-cell genomics. However, this method has been limited in its ability to ca...

The Potential of Nanomaterials to Activate the Body's Anti-tumor Immune Response

Dec 24, 2018 12:00 pm

The importance of research into the role of the immune system in the development and therapy of oncological diseases was emphasized by the Royal Swedish Academy, which recently named James Allison ...

An Innovative Tool Based on DNA Nanomachines to Peer Inside Lysosome

Dec 23, 2018 1:00 pm

The story of the lysosome is a classic smear campaign. Once dismissed as the garbage disposal of the cell—it does break down unneeded cell debris—it is now valued by scientists who real...

Neurology (692)

The Possible Common Mechanism between Fungal Infections and the Development of Chronic Neurological Disorders

Jan 12, 2019 2:00 pm

How Genes and Neurons Work in Concert to Pick Out a Particular Scent?

Jan 12, 2019 2:00 pm

The human nose can distinguish one trillion different scents—an extraordinary feat that requires 10 million specialized nerve cells, or neurons, in the nose, and a family of more than 400 ded...

New Compound Made of Cellular Prion Protein Shows Promise in Treatment of Alzheimer’s

Jan 10, 2019 4:00 pm

Yale researchers have identified a drinkable cocktail of designer molecules that interferes with a crucial first step of Alzheimer’s and even restores memories in mice, they report Jan. 2 in ...

Nutrition (126)

How Could AGEs Levels Impact ER-Positive Breast Cancer?

Jan 5, 2019 2:00 pm

Poor diet and lack of exercise are associated with cancer development, but the underlying biology is not well understood. Advanced glycation end products (AGEs) could offer a biological link to hel...

Folate Deficiency Drives More Problems in Connection with DNA Replication

Dec 19, 2018 11:00 am

Folate deficiency can severely affect one of the most important processes in the body, cell division, researchers from the University of Copenhagen have demonstrated in a new study published in the...

Time-Restricted Feeding May Reverse Diseases Related to Biological Clock Defects

Sep 13, 2018 10:00 am

LA JOLLA—Scientists at the Salk Institute found that mice lacking the biological clocks thought to be necessary for a healthy metabolism could still be protected against obesity and metabolic di...

Obesity (103)

What is the Link between Obesity, Senescence and Anxiety?

Jan 8, 2019 1:00 pm

Mayo Clinic researchers and collaborators have shown in mice that obesity increases the level of "zombie" or senescent cells in the brain, and that those cells, in turn, are linked to anx...

CRISPRa Fights Obesity Without Edits to Genome

Dec 29, 2018 2:00 pm

Removing RCAN1 Gene Might Be A Novel Approach Against Obesity

Dec 6, 2018 11:00 am

It sounds too good to be true, but a novel approach that might allow you to eat as much food as you want without gaining weight could be a reality in the near future. When a single gene known ...

Ophthalmology (42)

Injection of Short RNA Molecule Improves Vision in Leber Congenital Amaurosis

Dec 27, 2018 2:00 pm

Scientists Could Identify Hundreds of New Genes Linked to Blindness and Other Vision Disorders in Mice

Dec 25, 2018 12:00 pm

Hundreds of new genes linked to blindness and other vision disorders have been identified in a screen of mouse strains. Many of these genes are likely important in human eye vision and the results ...

Identifying Subtypes of Retinal Ganglion Cells by Single-Cell RNA Sequencing Technologies

Jul 28, 2018 1:00 pm

Single-cell sequencing technologies are filling in fine details in the catalog of life. Researchers at the University of Connecticut Health Center (UConn Health) and The Jackson Laboratory (JAX) ha...

Organizations / Institutions (147)

Agilent's New Chemical Imaging System Represents a Breakthrough in Both Chemical Imaging and Spectral Analysis

Dec 1, 2018 12:00 pm

Agilent Technologies Inc. (NYSE: A) today introduced a new approach to chemical imaging that will bring greater clarity and unprecedented speed to pharmaceutical, biomedical, food, and materials sc...

Merck’s Paired CRISPR Nickases Technique can Help us to Correct Genetic Defects in Gene Therapy Patients

Sep 27, 2018 10:00 am

Darmstadt, Germany, August 15, 2018 – Merck, the vibrant science and technology company, today announced that the Australian Patent Office has allowed the company’s patent application for ...

Alecensa® is a New Roche's Drug as an Initial Treatment for ALK

Sep 23, 2018 10:00 am

Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the China National Drug Administration (CNDA) has granted marketing authorisation for Alecensa® (alectinib) as a monotherapy treatment for p...

Osteology (23)

A Malfunctioning Gene May Associated with Ankylosing Spondylitis

Sep 4, 2018 11:00 am

New Drugs from FDA for Osteoarthritis Pain and Hypertension

Jun 28, 2018 5:30 pm

The US Food and Drug Administration (FDA) approved a combination of amlodipine besylate and the nonsteroidal anti-inflammatory drug (NSAID) celecoxib (Consensi, Kitov Pharma) for individuals with o...

Spinal Stimulation Helps Paralyzed Patients Regain Function

May 5, 2018 10:00 am

Once a person has suffered a spinal cord injury, there isn't much to be done except to learn how to live with paralysis and loss of function. That could change, thanks to the work of a team of sci...

Otolaryngology (4)

New Technique That Will Force The Centromere To Give Up Its Secrets

Dec 11, 2017 3:00 pm

A new technique may force the centromere -- the mysterious stretch of DNA in the center of every chromosome -- to give up its secrets at last. The first test of the approach has yielded clues about th...

How Sleep Apnea Can Be a Risk Factor for Diabetes?

Sep 19, 2017 10:00 am

Sleep apnea, left untreated for even a few days, can increase blood sugar and fat levels, stress hormones and blood pressure, according to a new study of sleeping subjects. This research adds further ...

Sensory cell regeneration, the new path in treating hearing loss.

May 20, 2017 2:00 pm

In an apparent first, St. Jude Children's Research Hospital investigators have used genetic manipulation to regenerate auditory hair cells in adult mice. The research marks a possible advance in t...

Parasitology (44)

Researchers Could Visualize a Key Molecular Structure Used by Malaria Parasite to Cause Infection

Dec 20, 2018 4:00 pm

An international team led by Institute researchers has visualised the unique molecular ‘key’ used by the world’s deadliest malaria parasite, Plasmodium falciparum, to enter and in...

Bone Marrow is a Major Reservoir for P. Vivax Malaria Parasite

Jul 9, 2018 2:00 pm

NEW YORK (Reuters Health) - Beyond blood, bone marrow is a major reservoir of the malaria parasite Plasmodium vivax, according to an international group of researchers. As Dr. Matthias Marti told R...

Two Proteins Recognize and Translate DNA Methylation Marks in Schistosoma Mansoni

Jul 5, 2018 1:00 pm

Two proteins that recognize and translate DNA methylation marks in Schistosoma mansoni are required for growth of adult stem cells in the parasitic flatworm, as well as production of eggs, accordin...

Pediatrics (87)

BabySeq Project identifies Children Susceptible to Diseases That Regular Screening Doesn’t Look for

Jan 6, 2019 2:00 pm

One Step Closer to The Super-Drug for Pediatric Leukemia

Dec 27, 2018 12:00 pm

Northwestern Medicine scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, according to three studies published over the last two years in ...

Healthy Blood Stem Cells Seem to Have as Many Mutations as Leukemic Cells!

Dec 2, 2018 11:00 am

Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ. Rather the location of th...

Pharmacogenetics (26)

A New Approach to Cancer Therapeutics by Targeting the Evolution of Cancer Cells

Dec 8, 2018 1:00 pm

Singapore – A team of scientists from Agency for Science, Technology and Research’s (A*STAR) Genome Institute of Singapore (GIS) has identified a new approach to cancer therapeutics by ...

A New Syndrome Uncovers the First Evidence Linking ODC1 Mutation and Developmental Problems in Humans

Dec 1, 2018 11:00 am

A Michigan State University pediatric researcher and a Spectrum Health physician have identified a new genetic syndrome in a 3-year-old girl who, for more than two years, has gone undiagnosed. ...

Lumoxiti, the First New Treatment Option for HCL's Patients in Over 20 Years

Sep 26, 2018 12:00 pm

AstraZeneca and MedImmune, its global biologics research and development arm, announced today that the US Food and Drug Administration (FDA) has approved Lumoxiti (moxetumomab pasudotox-tdfk) for the ...

Physiology (32)

How Does Every Single Cell in the Plant Know Its Growing Direction?

Dec 22, 2018 12:00 pm

Knowing which way is up or down is important for all living things. For plants, which grow roots into the soil and flowers above ground, getting this polarization wrong would cause a whole host of ...

Study Reveals a Newly Human Enzyme That Could Play a Key Role in Childbirth and Muscle Diseases

Dec 20, 2018 3:00 pm

Since the 1960s, scientists have known of a modification that occurs to a particular molecule in muscles, especially after exercise. What scientists haven’t known is how that modification hap...

The Epigenetic Mechanism Involved in Schizophrenia

Dec 17, 2018 11:00 am

A study using a PET scan tracer developed at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) has identified, for the first time, epigenetic differences between th...

Products & Technologies (595)

"HiDRA" A New Generalizable Method for Dissecting How Noncoding DNA Affects Gene Expression

Dec 25, 2018 3:00 pm

Approximately 98 percent of the human genome is made up of noncoding DNA, including enhancers, promoters, and other elements that regulate gene activity. The methods for studying these regions tend...

Study Reveals a New Improvement on Single-Cell RNA Sequencing

Dec 24, 2018 1:00 pm

Nanoscale Tweezers to Extract Single Molecules from Live Cells

Dec 22, 2018 1:00 pm

We are continuously expanding our knowledge on how cells function, but many unanswered questions remain. This is especially true for individual cells that are of the same type, such as brain, muscl...

Proteome & Proteomics (37)

The Role of Exosomes from Nischarin-Expressing Cells in Preventing Breast Cancer Growth and Spread

Jan 13, 2019 1:00 pm

Synapatic Protein That Regulates Anxiety Behaviors Offers a Therapeutic Target for Anxiety Disorders

Jan 7, 2019 1:00 pm

Scientists Discover New Brain Changes in Early Alzheimer's Disease

Jan 2, 2019 12:00 pm

Researchers at the University of Eastern Finland have identified new early stages of Alzheimer's disease in the human brain by combining the findings of RNA and protein found in omika analyzes ...

Psychology (120)

Potential Connection between PAC1R Mutation and Severity of Social Deficits in Autism

Jan 10, 2019 3:00 pm

A mutation of the gene PAC1R may be linked to the severity of social deficits experienced by kids with autism spectrum disorder (ASD), finds a study from a multi-institutional research team led by ...

New Insight into Early Development of Autism Spectrum Disorder

Jan 10, 2019 12:00 pm

What is the Link between Obesity, Senescence and Anxiety?

Jan 8, 2019 1:00 pm

Mayo Clinic researchers and collaborators have shown in mice that obesity increases the level of "zombie" or senescent cells in the brain, and that those cells, in turn, are linked to anx...

Pulmonary & Respiratory Medicine (36)

A Novel New Way to Treat Asthma

Sep 16, 2018 12:00 pm

An invisible particle enters your lungs. The next thing you know breathing becomes difficult. You are having as asthma attack. Asthma is one of the most common and difficult to endure chronic conditio...

Researchers Have Identified a Genetic Bio-markers to Test Asthma Simply & Accurately

Jun 20, 2018 8:00 pm

Mount Sinai researchers have identified a genetic biomarker of asthma that can be tested for using a simple nasal brush and basic follow-up data analysis. This inexpensive diagnostic test can accur...

Study Identifies New Molecular Target For Treating The Deadly Lung Disease "IPF"

May 2, 2018 12:00 pm

Scientists searching for a therapy to stop the deadly and mostly untreatable lung disease, idiopathic pulmonary fibrosis (IPF), found a new molecular target that slows or stops the illness in preclini...

Regenerative Medicine & Cell Therapy (50)

Stem Cell-Derived Neurons as a Potential Permanent Treatment for Epilepsy

Dec 22, 2018 3:00 pm

About 3.4 million Americans, or 1.2 percent of the population, have active epilepsy. Although the majority respond to medication, between 20 and 40 percent of patients with epilepsy continue to hav...

Scientists Could Identify the Epigenetic Control Mechanisms of How Neural Stem Cells Lose the Potential to Produce Neurons

Dec 19, 2018 12:00 pm

Scientists identified two distinct control mechanisms in the developmental transition of undifferentiated stem cells into healthy brain cells. This fundamental research using mice may inform regene...

Researchers Took an Important Step toward the Goal of Making Diseased Hearts Heal Themselves

Dec 17, 2018 12:00 pm

A team of Rutgers scientists, including Leonard Lee and Shaohua Li, have taken an important step toward the goal of making diseased hearts heal themselves – a new model that would reduce the ...

Scientists (7)

Dr. Amin Arnaout Recipient of The Prestigious Homer W. Smith Award

May 15, 2018 9:00 am

Dr. Amin Arnaout has been honored by the American Society of Nephrology (ASN) as recipient of the 2018 Homer W. Smith Award and recognized as “an individual who has made outstanding contribut...

Dr. Al-Zayani Receives The Venus Medical Award at a Ceremony In India

May 2, 2018 2:00 pm

Dr. Salman Hamad Al-Zayani, the Assistant Professor of Public Health at the College of Medicine and Medical Sciences at the Arabian Gulf University (AGU), has received the Venus International Medical ...

The Brain Prize This Year Goes To Alzheimer's Researchers

Mar 11, 2018 9:00 am

Four dementia scientists have shared this year's 1m Euro brain prize for pivotal work that has changed our understanding of Alzheimer's disease. Profs John Hardy, Bart De Strooper, Michel G...

Single Nucleotide Polymorphisms (13)

Low Genetic Diversity Put the Singapore Freshwater Crab Under the Threat of Extinction

Jun 24, 2018 4:00 pm

Researchers from NUS and National Parks Board (NParks) have established that the critically endangered Singapore freshwater crab (Johora singaporensis) does not mix or breed between different popul...

Mendelian Randomization Analysis to More Precision and Less Time and Cost

Jun 7, 2018 1:00 pm

The evolution of medicine relies heavily on the results of clinical trials, which while essential, are extremely costly and carry the potential of unintended adverse consequences. Now researchers from...

Mutations Other Than BRCA Can Cause Second Primary Breast Cancer

Jun 6, 2018 5:00 pm

Rates of inherited mutations in genes other than BRCA1/2 are twice as high in breast cancer patients who have had a second primary cancer—including, in some cases, different types of breast c...

Stem Cells & Cancer Stem Cells (213)

New Insight into Early Development of Autism Spectrum Disorder

Jan 10, 2019 12:00 pm

Cutting Off the Blood Supply to the Cancer Could Stop Melanoma from Spreading

Jan 8, 2019 12:00 pm

Stopping melanoma from spreading to other parts of the body might be as simple as cutting off the blood supply to the cancer, according to researchers. Scientists from The University of Queens...

New Stem-cell-based Test to Personalize Clinical Care for Family with Cardiomyopathy

Dec 27, 2018 4:00 pm

PHILDELPHIA – A little over a year ago, a 65-year-old woman with severe hypertrophic cardiomyopathy—a condition in which the heart’s muscle becomes abnormally thick, potentially c...

Toxicology (34)

How the Distance of Microbial Competitions Shapes Their Community Structures?

Dec 8, 2018 10:00 am

Inside the microbial communities that populate our world, microbes are fighting for their lives. These tiny organisms are in the soil, in the oceans, and in the human body. Microbes play sever...

Impacts of highly Hazardous Pollutants Dioxins on Plants

Sep 9, 2018 11:00 am

Dioxins are highly hazardous pollutants that have well characterized impacts on both animal and human health. However, the biological effects of dioxins on plants have yet to be described in detail. ...

Prenatal Exposure to the DDT Toxin may be Related to Autism

Sep 4, 2018 10:00 am

National birth cohort study finds DDT metabolites in the blood of pregnant women are associated with elevated odds of autism in offspring. A study of more than 1 million pregnancies in Finland...

Transcriptome & Transcriptomics (10)

Scientists Discover a Group of Genes Involved in Regeneration That Are Kept in Different Species

Dec 8, 2018 2:00 pm

Researchers from the Department of Genetics, Microbiology and Statistics and the Institute of Biomedicine of the University of Barcelona (UB), in collaboration with the Centre for Genomic Regulatio...

A New Approach to Cancer Therapeutics by Targeting the Evolution of Cancer Cells

Dec 8, 2018 1:00 pm

Singapore – A team of scientists from Agency for Science, Technology and Research’s (A*STAR) Genome Institute of Singapore (GIS) has identified a new approach to cancer therapeutics by ...

A New Research Reveals Cellular Gene Signatures that Could Be the Key to Understand the Ability of Heart Muscle Repair

Dec 3, 2018 4:00 pm

Repairing heart muscle damaged by a heart attack or other cardiovascular diseases is one of the “holy grails” for cardiovascular scientists. The ability to repair heart muscle – e...

Urology (12)

Frequencies of APOL1 Renal Risk Variants Affect More Populations than Previously Thought

Dec 30, 2018 12:00 pm

New York, NY (December 27, 2018) In the largest population genomics investigation to date, a team of researchers at the Icahn School of Medicine at Mount Sinai, Stanford University, and the Univers...

Genetic Mutations Could Play a Vital Role in Improving Diagnosis of Prostate Cancer Patients

Sep 17, 2018 10:00 am

Scientists have discovered a link between certain genetic mutations, the aggressiveness of prostate cancer, risk of developing the disease and poorer survival rates of patients. The gene, called ANO7,...

Disabled Kidney Function May Cause Diabetes

Dec 16, 2017 4:00 pm

Diabetes is known to increase a person's risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunc...

Vaccines (57)

A Live Genetically Engineered Vaccine Promises to Be Effective Against Chikungunya Virus

Dec 27, 2018 3:00 pm

Scientists Develop an HIV Vaccine that Can Protect Non-human Primates from Infection

Dec 24, 2018 2:00 pm

LA JOLLA, CA – For more than 20 years, scientists at Scripps Research have chipped away at the challenges of designing an HIV vaccine. Now new research, published in Immunity, shows that thei...

Researchers Could Visualize a Key Molecular Structure Used by Malaria Parasite to Cause Infection

Dec 20, 2018 4:00 pm

An international team led by Institute researchers has visualised the unique molecular ‘key’ used by the world’s deadliest malaria parasite, Plasmodium falciparum, to enter and in...

Virology (200)

Researchers Discover New Connections between Ebola Virus and Human Proteins

Jan 5, 2019 12:00 pm

Using CRISPR to Modify Pig Genome Shows Promise Against Deadly Disease

Jan 3, 2019 1:00 pm

Chinese scientists recently reported that they have developed genetically modified pigs that are immune from the classical swine fever virus (CSFV). Classical swine fever, caused by CSFV, is h...

A Live Genetically Engineered Vaccine Promises to Be Effective Against Chikungunya Virus

Dec 27, 2018 3:00 pm

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